Sending, receiving, and organizing email in Outlook on the web for business
The steps to unblock the mailbox will depend on why it was blocked, as there are several possible causes (for example, outbound spam detection, sending limits, tenant restrictions, transport rules, or a mailbox-specific block).
Could you please provide the full Non-Delivery Report (NDR) or error message that is being returned when sending emails? Do you meet this issue when sending to external, internal users or both?
For example:
550 5.7.233 Your message can't be sent because your tenant exceeded its daily limit for sending email to external recipients (tenant external recipient rate limit).
I look forward for your reply.