Configuring preferences and options in Outlook.com
Using my wife's email account and Edge browser I was finally able to reach Outlook chat. After an hour this was their reply:
Thank you for your patience, Ed. I have consulted with our Tier 2 team and they confirmed that this is a known issue affecting some Outlook.com users. We have received multiple reports of customers being unable to save changes to their Safe Senders or Blocked Senders lists and receiving the message: "Couldn't save changes. Something went wrong. Please try again later."
Our engineering team has already identified the root cause and a fix is currently being rolled out to affected accounts.
So hopefully all of us with this issue will get the fix soon.
Thanks.