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To better understand your situation, may I clarify a few details with you?
1.If you’re using an on-premises Exchange Server, could you please confirm the Exchange Server version and Cumulative Update (CU)?
2.Are you using Outlook for Windows or Outlook for Mac?
3.Does this issue affect only one user, or are other users experiencing the same issue?
4.Can you access your mailbox through Outlook on the web (OWA)? If so, are you able to send and receive emails normally there?
5.Are you the Exchange Server administrator, or are you an end user?
For your reference, the following checklist is related to administrator‑side tasks:
-Check the overall health of the Exchange Server, including required services, IIS status, Exchange application pools, as well as IIS and Event Viewer logs.
-Verify Autodiscover and DNS configuration, including the Autodiscover SCP, internal and external DNS records, and whether autodiscover.domain.com and mail.domain.com resolve correctly.
-Review the Exchange certificate to ensure it is valid, not expired, includes the required names such as mail.domain.com and autodiscover.domain.com, and is properly assigned to IIS.
-Confirm the Exchange virtual directories and MAPI over HTTP configuration, including OWA, ECP, EWS, OAB, ActiveSync, MAPI, Outlook Anywhere URLs, and authentication settings.
In the meantime, you may also run a quick test using the Microsoft Remote Connectivity Analyzer to gather additional insight.
If you have any updates or further details, please feel free to share them.