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Hi,
Based on the 403 response, this looks like a Microsoft Defender XDR Unified RBAC permission issue, rather than only an Azure RBAC permission on the Sentinel workspace.
The error specifically shows the missing permissions:
microsoft.xdr/configuration/security/detectiontuning/manage microsoft.xdr/secops/securitydata/automation/rules/manage
I would check Microsoft Defender portal → System → Permissions → Microsoft Defender XDR → Roles and verify that the user has a Unified RBAC role containing the required manage permissions and that the role assignment is scoped to the relevant Microsoft Sentinel workspace.
Also verify under System → Permissions → Microsoft Defender XDR → Workload settings that Microsoft Sentinel is activated for Unified RBAC.
Once Sentinel is activated for Unified RBAC, permissions for the Defender portal experience are managed through Unified RBAC, so having the appropriate Azure RBAC role on the Log Analytics workspace alone might not be sufficient.
Microsoft documentation: Activate Microsoft Defender XDR Unified RBAC Configure Microsoft Sentinel scoping and permissions
I would start by checking the Unified RBAC role assigned to securityadmin1 and its scope.