Hello @Trabucco Walter (Genertel)
The primary mouse button setting is usually user/session-specific, so the local PC's left-handed mouse configuration may not carry over automatically into an RDP session.
Inside the remote session, try Settings → Bluetooth & devices → Mouse → Primary mouse button → Right. This makes the right button the primary/select button for that remote Windows user.
You can also verify the setting inside the RDP session with:
control mouse
Then check Switch primary and secondary buttons.
If the setting works but resets at every sign-in, the issue is likely profile persistence or Group Policy/session management, not RDP mouse redirection itself. In that case, check whether the remote user's profile is persistent and whether a policy or logon script is resetting the mouse configuration.
Microsoft documents that mouse settings are configured per Windows user through the Windows mouse settings interface.
Reference: Microsoft Support - Change mouse settings
If you can confirm whether this is standard RDP, Remote Desktop Services, or Azure Virtual Desktop, and whether the setting resets after reconnecting, we can narrow it down further.
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