Dear @Dan Zanger,
Thank you for posting your question in the Microsoft Q&A forum.
Based on your description, this error indicates that Outlook for Windows cannot connect to your education (Exchange) mailbox because the local Outlook profile contains missing or incorrect Exchange configuration information. This commonly occurs when the Outlook profile is corrupted or still referencing outdated server or Autodiscover settings.
Have you tried to switch to New Outlook to check whether the issue still persists or not?
Here are some troubleshooting steps you can refer to:
Verify mailbox access via Outlook on the web (OWA) Sign in to your education mailbox using Outlook on the web.
If OWA works but the desktop app does not, the issue is likely limited to the Outlook client or profile.
Try to create a new Outlook profile
Close Outlook
Open Control Panel > Mail (Microsoft Outlook) > Show Profiles
Select Add to create a new profile
Add your education account and set the new profile as the default
Restart Outlook
If the issue persists after creating a new profile and if Outlook on the web (New outlook) works but a newly created profile still shows the same error, the issue is likely on the server or tenant side. In this case, please contact your school’s IT administrator to verify:
The mailbox is active and properly provisioned
Autodiscover and Exchange configuration are correct
There are no recent migrations or changes impacting Outlook connectivity
I hope information above can meet your expectations, please feel free to reach out if you have any other questions.
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