A family of Microsoft relational database management systems designed for ease of use.
I assume you have tried compacting and repairing the database with File | Info | Compact & Repair Database.
Is the database split into separate front and back ends? This is advisable, even in a single user environment, as, in the event of the front end becoming corrupted, the data will be unaffected.
If the database is split, and you experience the error when opening the front end, you might be able to refresh the links to the back end with the built in Linked Table Manager. If not, then the front end might have become corrupted, in which case try creating a new empty database file, and then import all objects from the current front end file into it via the External Data ribbon.
If the database is not split, then again try creating a new database and importing all objects into it.