You can customize your Azure-SQL Server Integration Services (SSIS) Integration Runtime (IR) in Azure Data Factory (ADF) or Synapse Pipelines via custom setups. They allow you to add your own steps during the provisioning or reconfiguration of your Azure-SSIS IR.
The IBM iSeries Access ODBC driver is not supported on the Azure-SSIS IR. You might see installation errors during your custom setup. If you do, contact IBM support for assistance.