Can I subscribe Defender Plan II and Intune Plan I standalone without subscribing whole E3 or E5 package?

Standalone licenses are possible. However, you should check with your licensing partner or MS to confirm.

@ashish shukla, Thanks for posting in Q&A. For your question, of course you can. Here are the links you can try the standalone licenses.

https://www.microsoft.com/en-us/security/business/microsoft-intune-pricing?msockid=1e0bddf9f234641717dbcc33f3b165cc

https://www.microsoft.com/en-us/security/business/endpoint-security/microsoft-defender-endpoint?msockid=1e0bddf9f234641717dbcc33f3b165cc

But based on my experience, some functions need not just standalone license. But some addition licenses. For example, from Intune side, to manage the device in Intune, the device needs to be firstly enrolled into Intune. Like Windows automatic enrollment, it needs additional Microsoft Entra Premium license.

https://learn.microsoft.com/en-us/mem/intune/fundamentals/deployment-guide-enrollment-windows

To ensure you get the most suitable license, you can consider contacting license support and provide all your requirements to find the most suitable one.

https://learn.microsoft.com/en-us/licensing/licensing-orders-invoices-payments-support

Hope the above information can help.

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