@Aran Billen, Thanks for posting in Q&A.
From your description, I know you have enrolled your macOS devices in Intune and want to configure them before user's login in.
Based on my research, here is a link about how to configure device settings and deploy apps you can refer.
https://learn.microsoft.com/en-us/mem/intune/apps/apps-company-portal-macos
Please note that if you want to deploy some configuration profiles or apps once before user sign in, you can create a device group and assign them to the device group, however, some settings or apps have to assign to user group which means users must sign in the device to sync with Intune to get policies and apps applied.
Hope it will help.
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